While naringin has become most popular for its synergistic effects with other supplements, especially caffeine, it's quickly gaining ground for its other potential benefits. In particular, its ability to support healing of our tissues after intense, grueling workouts. But make no mistake, the best reason to be interested in naringin is to increase the effectiveness of the other supplements you may be taking.
Other names for Naringin
citrus bioflavonoid, grapefruit peel, orange peel
Where to find Naringin
Naringin is a flavonoid extracted from the inner peel of grapefruit and other citrus fruits (albeit in lower amounts).
Much of the early research into citrus-fruit flavonoids was funded by the Florida orange juice industry looking for a commercial use for orange peel. Grapefruit product manufacturers try to use fruits with low naringin content since it causes the bitterness characteristic of citrus fruits. The food industry, however, uses naringin as a bitter in "tonic" beverages, bitter chocolate, ice cream, and ices.
Why athletes use Naringin
Interested in saving some cash by increasing the potency and lifespan of your supplements? Look no further. Naringin does just that and more.
Ways that Naringin can enhance Fat Loss:
- Reduce hunger while potentially enhancing the flavor of foods by stimulating the taste buds
Ways that Naringin can enhance Longevity:
- Extend the life of supplemented nutrients and increase their potency
Signs of Naringin deficiency
No deficiency conditions are known to exist.
Potential uses for Naringin
Research indicates that Naringin may be useful in the treatment of:
More about Naringin
Naringin is a bioflavonoid, arguably one of the most important emerging classes of nutrients. While mostly promoted for its dramatic effect on the absorption and uptake of supplements — increasing their effectiveness — that's just part of the whole story...
What is naringin?
Naringin belongs to a group of chemicals called bioflavonoids, which are colorful pigments found in plants. They were discovered by Nobel Prize-winning biochemist Albert Szent-Gyorgi, who labeled them "vitamin P" (although they were subsequently stripped of their vitamin status). Bioflavonoids belong to a larger group of phytochemicals called polyphenols. Key polyphenols include phenolic acids, flavonoids, stilbenes, and lignans. Flavonoids are the most abundant polyphenols in our diets.
Flavonoids work as powerful antioxidants, protecting the body from free radicals. Flavonoids also strengthen capillary walls, assisting circulation and helping prevent bruising and bleeding, and some flavonoids are strong anti-inflammatory agents, helping control damage to tissues. Citrus bioflavonoids are thought to work by strengthening the walls of blood vessels.
Increased uptake of supplements
Naringin is most commonly used in the nutrition industry to increase uptake of supplements such as caffeine for added performance. It works by interfering with the activity of enzymes in the intestines and thus the breakdown of nutrients and supplements, which leads to higher levels of these compounds in the body.
Naringin also appears to work as an aldose reductase inhibitor, which inhibit the enzyme that turns glucose into other sugars that can't leave the cell — thereby allowing it to drain away safely, preventing damage. Alpha-lipoic acid (ALA) is another aldose reductase inhibitor that's used to control blood sugar.
Naringin's properties may explain the popularity and possible benefits of the grapefruit diet during the 1970's. People used grapefruit juice to reduce appetite for weight loss and enhance taste sensation because the naringin in the juice stimulates the taste buds.
Studies financed by Tropicana are finding that naringin in citrus juice may increase levels of good (HDL) cholesterol. Boosting levels of HDL cholesterol slows accumulation of artery-clogging plaque and may support long-term heart health. On the downside: if you drink too much fruit juice, you jack up your blood sugar and consume a great deal of extra sugary carbs. As a solution, researchers are making supplements that offer the benefits of naringin and other citrus bioflavonoids without the high sugar levels found in citrus fruits. In fact, the juice isn't even the best source of naringin anyway: higher levels are found in the peel.
Citrus bioflavonoids like naringin may also help prevent and heal injuries, including bruising and bleeding by maintaining capillaries, which are microscopic blood vessels that allow oxygen, nutrients, hormones, and antibodies to pass from the blood into cells. If capillary walls are too fragile, they will allow blood to drain out of the vessels and into the cells, causing easy bruising and bleeding.
While naringin has become most popular for its synergistic effects with other supplements, especially caffeine, it's quickly gaining ground for its other potential benefits. In particular, its ability to support the healing of our tissues after intense, grueling workouts. But make no mistake, the best reason to be interested in naringin is to increase the effectiveness of the other supplements you may be taking.
A typical amount of naringin supported by research is 500 mg 2 times a day; however, when combined in a formula with other supplements, it's quite common to use 50 to 100 mg per serving.
Absorption of naringin from grapefruit juice varies from 5% to 57%, depending on the individual, so supplementation is a better way to get a standardized, reliable dose.
In general, naringin should be consumed with meals or supplement formulas because whole foods or other nutrients support maximum benefits of bioflavonoids.
Synergists of Naringin
Naringin is used specifically because it is synergistic with many other supplements; that is, it raises blood levels of the supplements in the body and thus their overall effectiveness.
Caffeine levels and effects of caffeine in particular appear to be greatly extended by consuming naringin. Specifically, it prolongs how long caffeine remains active in the body by 31%. This is why you often see it in fat-loss products.
Flavonoids, particularly citrus bioflavonoids like naringin, are often taken with Vitamin C to combat colds, bleeding problems, bruising, and ulcers.
Drugs that interact with Naringin
A recent discovery is that naringin changes the dose of many drugs by affecting their metabolism. A number of drugs that are known to be affected by naringin include calcium channel blockers, anti-fungal agents, antibiotics, estrogen, sedatives, medications for high blood pressure, allergies, AIDS, and cholesterol-lowering drugs. For example, the body's use of the drug cyclosprorine increases 62% when taken with grapefruit juice. Of course, this can be good news if you know what you're doing because this would make drug use cheaper and more effective — lower dosages being needed for the same effects. But before you use naringin with drugs, be sure to consult with your health professional.
Toxicity of Naringin
No known toxicity.
Bans and restrictions
- Bear, W.L., and Teel, R.W., "Effects of Citrus Flavonoids on the Mutagenicity of Heterocyclic Amines and on Cytochrome P450 1A2 Activity," Anticancer Res 20.5B (2000) : 3609-14.
- Choi, M.S., et al., "Effect of Naringin Supplementation on Cholesterol Metabolism and Antioxidant Status in Rats Fed High Cholesterol with Different Levels of Vitamin E," Ann Nutr Metab 45.5 (2001) : 193-201.
- da Silva, R.R., et al., "Hypocholesterolemic Effect of Naringin and Rutin Flavonoids," Arch Latinoam Nutr 51.3 (2001) : 258-64.
- Fuhr, U., et al., "Inhibitory Effect of Grapefruit Juice and Its Bitter Principal, Naringenin, on CYP1A2 Dependent Metabolism of Caffeine in Man," Br J Clin Pharmacol 35.4 (1993) : 431-6.
- Fuhr, U., and Kummert, A.L., "The Fate of Naringin in Humans: A Key to Grapefruit Juice-Drug Interactions?" Clin Pharmacol Ther 58.4 (1995) : 365-73.
- Nijveldt, R.J., et al., "Flavonoids: A Review of Probable Mechanisms of Action and Potential Applications," Am J Clin Nutr 74.4 (2001) : 418-25.